高云飞 研究员

职称：研究员

学科专业：免疫学

研究方向：

1、T细胞在肿瘤免疫中的作用

2、肿瘤细胞代谢与肿瘤免疫逃逸机制

3、免疫细胞治疗

电子邮箱：tyunfeigao@jnu.edu.cn

个人介绍：高云飞，细胞生物学博士，暨南大学研究员、博士生导师。主要研究方向为T细胞在肿瘤免疫中的作用；肿瘤细胞代谢与肿瘤免疫逃逸机制；免疫细胞治疗。以通讯作者在JCI、Science Bulletin、JITC、Molecular Therapy以及Theranostics等国际著名杂志发表研究论文多篇，获批国家自然科学基金3项，获授权国家发明专利3项。

学习经历：

1983-1987 兰州大学细胞生物学 学士

1987-1990 兰州大学发育生物学 硕士

1998-2001 北京大学细胞生物学 博士

工作经历：

2002-2005 美国耶鲁大学医学院内科学系，博士后

2005-2009 加拿大多伦多大学免疫学系，博士后

2009-2013 加拿大多伦多玛格丽特公主医院坎贝尔乳腺癌研究所，助理研究员

2013-至今 暨南大学生物医学转化研究院，研究员，博导

主要论文：

[1] Li Peng, Ke Li, Wenhui Yuan, Yuqi Xu, Li, Ruan Wu, gru Han, Zhinan Yin, Ligong Lu, and Yunfei Gao#. 1α, 25 (OH) 2D3 ameliorates insulin resistance by alleviating γδ T cell inflammation via enhancing fructose-1, 6-bisphosphatase 1 expression.Theranostics13, no. 15 (2023): 5290.

[2]Zhou, Wei, Hua Zhang, Lihua Huang, Chuankai Sun, Yuhan Yue,Xiaolei Cao, Hongling Jia#, Chunyue Wang#, and Yunfei Gao#. Disulfiram with Cu2+ alleviates dextran sulfate sodium-induced ulcerative colitis in mice.Theranostics13,no.9(2023):2879.

[3]Xia, X., Zhang, Y., Zhu, L., Ying, Y., Hao, W., Wang, L., He, L., Zhao, D., Chen, J.X., Gao, Y#. and Huang, J.Q., 2023. Liquiritin apioside alleviates colonic inflammation and accompanying depression-like symptoms in colitis by gut metabolites and the balance of Th17/Treg.Phytomedicine,120, p.155039.

[4]Zhang,Hua,RenwenZhang,XujiaZeng,XiaoWang,DeshengWang,HonglingJia#,WeiguoXu#,andYunfeiGao#.Exposure to neonicotinoid insecticides and their characteristic metabolites : Association with human liver cancer.Environmental Research208(2022):112703.

[5]Li,P.,Zhu,X.,Cao,G.,Wu,R.,Li,K.,Yuan,W.,...&Gao,Y#.1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells.Journal for immunotherapy of cancer, (2022).10(3).

[6]Zhang, Hua, **gxia Li, Yulin An, Desheng Wang, Jianfu Zhao, Meixiao Zhan, Weiguo Xu#, Ligong Lu#, and Yunfei Gao#. Concentrations of bisphenols, benzophenone-type ultraviolet filters, triclosan, and triclocarban in the paired urine and blood samples from young adults: Partitioning between urine and blood.Chemosphere288 (2022): 132563.

[7]Jia,Hongling; Liu,Chaowu; Li,Dantong; Huang,Qingsheng; Liu,Dong; Zhang,Ying; Ye,Chang; Zhou,Di; Wang,Yang; Tan,Yanlian; Li,Kuibiao; Lin,Fangqin; Zhang,Haiqing; Lin,Jingchao; Xu,Yang; Liu,Jingwen; Zeng,Qing; Hong,Jian; Chen,Guobing; Zhang,Hao; Zheng,Lingling; Deng,Xilong; Ke,Changwen; Gao,Yunfei#; Fan,Jun#; Di,Biao#; Liang,Huiying#. Metabolomic analyses reveals new stage-specific features of the COVID-19.European Respiratory Journal, 2021,59: 2100284

[8]Li,Peng; Wu,Ruan; Li,Ke; Yuan,Wenhui; Zeng,Chuqian; Zhang,Yuting; Wang,Xiao; Zhu,Xinhai; Li,Ping#; Gao,Yunfei#. IDO Inhibition Facilitates Antitumor Immunity of Vg9Vd2 T Cells in Triple Negative Breast Cancer.Frontiers in Oncology, 2021, 11:679517.

[9]Zhang,Hua; Li,Jingxia; Chen,Yanfang; Wang,Desheng; Xu,Weiguo#; Gao,Yunfei#. Profiles of parabens , benzophenone-type ultraviolet filters , triclosan , and triclocarban in paired urine and indoor dust samples from Chinese university students : Implications for human exposure.Science of the Total Environment,2021,798:149275.

[10]Lu,Ligong#;Li,Zhizhong#;Gao,Yunfei#.Profiles of neonicotinoid insecticides and their metabolites in paired saliva and periodontal blood samples in human from South China:Association with oxidative stress markers.Ecotoxicology and Environmental Safety,2021,212:112001.

[11]Zhang,Hua; Shen,Kui; Wu,Ruan; Li,Zhiyong; Wang,Xiao; Wang,Desheng; Zhan,Meixiao; Xu,Weiguo#; Gao,Yunfei#; Lu,Ligong#. Occurrence and distribution of neonicotinoids and characteristic metabolites in paired urine and indoor dust from young adults: Implications for human exposure.Environmental Research, 2021, 199: 111175.

[12]Lu,Feng;Zhou,Qian;Liu,Lu;Zeng,Guandi;Ci,Weimin;Liu,Wanting;Zhang,Gong;Zhang,Zhiyi;Wang,Peng;Zhang,Aiqun;

Gao,Yunfei#.Yu,Lei#;He,Qingyu#;Chen,Liang#;A tumor suppressor enhancing module orchestrated by GATA4 denotes a therapeutic opportunity for GATA4 deficient HCC patients.Theranostics,2020,10(2):484-497.

[13]Zhang,Hua; Quan,Qiang; Li,Xiaowei; Sun,Wenjing; Zhu,Kairui; Wang,Xiao; Sun,Xufang; Lu,Ligong#; Fan,Jun#; Gao,Yunfei#. Occurrence of parabens and their metabolites in the paired urine and blood samples from Chinese university students: Implications on human exposure.Environmental Research, 2020, 183:109288.

[14]Xia,Xichun; Cao,Guangchao; Sun,Guodong; Zhu,Leqing; Tian,Yixia; Song,Yueqi; Guo,Chengbin; Wang,Xiao; Zhong,Jingxiang; Zhou,Wei; Li,Peng; Zhang,Hua; Hao,Jianlei; Li,Zhizhong; Deng,Liehua#; Yin,Zhinan#; Gao,Yunfei#. GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.Journal of Clinical Investigation, 2020, 130(10):5180-5196.

[15]Zhang,Hua; Sun,Guodong; Li,Xiaowei; Fu,Zhen; Guo,Chengbin; Cao,Guangchao; Wang,Baocheng; Wang,Qian; Yang,Shuxian; Li,Dehai; Xia,Xichun; Li,Peng; Zhu,Jing; Zhou,Wei; Zheng,Liangyan; Li,Jingxia; Zhang,Lei; Hao, Jianlei; Zhou,Libing; Bornancin,Frederic; Li,Zhizhong#; Yin,Zhinan#; Gao,Yunfei#. Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury.Science Bulletin, 2019,64(16):1179-1194.

[16]Zhang,Hua; Li,Yuanyuan; Zhu,Jing; Li,Heng; Li,Dehai; Liu,Zhaoxiang; Sun,Xufang; Wang,Baocheng#; Wang,Qian#; Gao,Yunfei#. Disposable Pipette Extraction(DPX) Coupled with Liquid Chromatography-Tandem Mass Spectrometry for the Simultaneous Determination of Pesticide Residues in Wine Samples.Food Analytical Methods, 2019,12(10):2262-2272.

[17]Zhang, Hua; Zhang, Nan; Zhou, Wei; Zeng, Xujia; Wang, Xiao; Zhan, Meixiao; Xu, Weiguo; Lu, Ligong#; Li, Zhizhong#; Gao, Yunfei#. Profiles of neonicotinoid insecticides and their metabolites in paired saliva and periodontal blood samples in human from South China: Association with oxidative stress markers.Ecotoxicology and Environmental Safety, 2021, 212: 112001.

[18]Xia,Xichun; Zhou,Wei; Guo,Chengbin; Fu,Zhen; Zhu,Leqing; Li,Peng; Xu,Yan; Zheng,Liangyan; Zhang,Hua; Shan,Changliang; Gao,Yunfei#. Glutamino lysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion.Frontiers in Oncology, 2018, 8: 632.

[19] Gao Y＊., Majchrzak-Kita B., Fish E., and Gommerman J#. Dynamic Accumulation of Plasmacytoid Dendritic Cells in Lymph Nodes is regulated by Type I IFN-beta. Blood2009, 114(13): 2623-2631

[20] Gao Y＊., Yang W., Pan M., Scully E., Girardi M., Augenlicht L., Craft J., and Yin Z#. T cells provide an early source of IFN- in tumor immunity. J. Exp. Med. 2003, 198(3): 433-442

获奖及荣誉：

曾获得国际干扰素和细胞因子研究学会（ISICR）的Travel Award，加拿大多发性硬化病学会的 Postdoctoral Fellowship。

学术兼职：

1.中国免疫学会会员

2.中国细胞生物学会会员

3.广东省免疫学会会员

导师类型（博导/硕导）：博导