杨美香 研究员

职称：研究员

学科专业：免疫学

研究方向：

1． 膳食结构调控对固有免疫细胞功能的影响

2． 转录因子调控自然杀伤细胞发育和功能的机制研究

3． 代谢相关信号通路调控自然杀伤细胞发育和功能的时序性研究

电子邮箱：mxyang@jnu.edu.cn

个人介绍：暨南大学研究员，博士生导师，广东省免疫学会第六届理事会理事，广东省免疫学会女科学家工作委员会委员，“暨南双百英才计划”杰出人才。实验室研究方向主要包括代谢信号通路相关分子和转录因子调控自然杀伤细胞发育和功能的机制研究，获得多项国家自然科学基金项目以及省部级课题资助，研究成果在免疫学权威期刊“Immunity”，”Journal of Experimental Medicine”，”Nature Communications”等发表。

学习经历： 

2007.09-2010.07：博士，山东大学，免疫学

2000.09-2003.07：硕士，山东省医学科学院，免疫学

1995.09-2000.07：学士，泰山医学院，临床医学

工作经历：

2015.09-至今：暨南大学  研究员博士生导师 （2015年9月第四层次人才引进，“暨南双百英才计划”杰出人才）

2017.10-2019.07： 加州大学圣地亚哥分校 访问学者

2011.09-2015.09：  清华大学医学院，博士后

2003.07-2011.09： 山东大学齐鲁医院临床基础研究所，副主任技师

主持课题：  

1. 杨美香，等. “肝激酶LKB1调控自然杀伤细胞代谢稳态维持其发育和抗肿瘤能力的机制探讨”广东省自然科学基金面上项目.【项目编号：2024A1515010566】2024年-2026年

2.杨美香，等.“IL-15激活非经典Hippo信号通路调控肝脏NK/ILC1细胞发育的机制研究.” 国家自然科学基金面上项目.【项目编号：82271754】2023年-2026年.

3.杨美香，等.“转录因子TOX调控自然杀伤细胞功能耗竭的机制探讨.” 国家自然科学基金面上项目.【项目编号：82071737】2021年-2024年.

4.杨美香，等.“T-box家族转录因子Eomes和T-bet调控自然杀伤细胞发育和功能的机制研究.” 国家自然科学基金面上项目.【项目编号：81771666】2018年-2020年.

5.杨美香，等.“饮食限制对自然杀伤细胞功能的影响及其机制探讨”广东省自然科学基金-面上项目. 【项目编号：2019A1515011707】2019年-2022年.

6.杨美香，等. “PI3K-mTOR信号通路相关分子调控自然杀伤细胞发育和功能的时序性研究.”广州市科技计划项目.【项目编号：201707010395】 2017年-2019年.

7.杨美香，等.“自然杀伤细胞发育分化和免疫记忆形成的代谢调节.”国家自然科学基金面上项目.【项目编号：81471523】2015年-2018年.

8.杨美香, 等. “NK细胞稳态增殖的分子机制探讨.” 51批中国博士后科学基金面上项目. 【项目编号：2012M510466】2011年-2014年.

9.杨美香，等. “Tim-3-Galectin-9通路在妊娠早期母-胎界面免疫调控中的作用研究.” 国家自然科学基金青年基金.【项目编号：30901326】2009年-2011年.

主要论文：

1.Feng P, Luo L, Yang Q, Meng W, Guan Z, Li Z, Sun G, Dong Z, Yang M. Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity. Cell Death Dis. 2024 Jun 19;15(6):430. (共同通讯作者)

2.Xiao Z, Wang S, Luo L, Lv W, Feng P, Sun Y, Yang Q, He J, Cao G, Yin Z, Yang M. Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis. Cell Mol Immunol. 2024 Jun;21(6):546-560. (共同通讯作者)

3.He J, Chen D, Xiong W, Hou X, Quan Y, Yang M, Dong Z. Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively. Cell Mol Immunol. 2024 May 13. (共同通讯作者) 一区 影响因子21.8

4.Wan S, Sun Y, Zong J, Meng W, Yan J, Chen K, Wang S, Guo D, Xiao Z, Zhou Q, Yin Z, Yang M. METTL3-dependent m6A methylation facilitates uterine receptivity and female fertility via balancing estrogen and progesterone signaling. Cell Death Dis. 2023 Jun 3;14(6):349. (共同通讯作者)

5. Luo L, Feng P, Yang Q, Lv W, Meng W, Yin Z, Li Z, Sun G, Dong Z, Yang M. Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development. Theranostics. 2023 13(7):2072-2087. (共同通讯作者)

6. Wan S, Sun Y, Zong J, Meng W, Yan J, Chen K, Wang S, Guo D, Xiao Z, Zhou Q, Yin Z, Yang M. METTL3-dependent m6A methylation facilitates uterine receptivity and female fertility via balancing estrogen and progesterone signaling. Cell Death Dis. 2023 Jun 3;14(6):349.(共同通讯作者)

7. Xiao Z, Wang S, Tian Y, Lv W, Sheng H, Zhan M, Huang Q, Zhang Z, Zhu L, Zhu C, Zhong H, Wen Q, Liu Z, Tan J, Xu Y, Yang M, Liu Y, Flavell RA, Yang Q, Cao G, Yin Z. METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells. Cell Rep. 2023 Jul 25;42(7):112684.

8. Wan S, Sun Y, Fu J, Song H, Xiao Z, Yang Q, Wang S, Yu G, Feng P, Lv W, Luo L, Guan Z, Liu F, Zhou Q, Yin Z, Yang M. mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation. Cell Death Dis. 2022 Oct 11;13(10):862.(共同通讯作者)

9. Xin B, Yang M, Wu P, Du L, Deng X, Hui E, Feng GS. Enhancing the Therapeutic Efficacy of PD-L1 Antibody for Metastasized Liver Cancer by Overcoming Hepatic Immunotolerance. Hepatology. 2022 Sep; 76(3):630-645.

10. Luo Z, Ji Y, Zhang D, Gao H, Jin Z, Yang M, Ying W. Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis. Acta Physiol (Oxf). 2022 Jul;235(3):e13827.

11. Hanley KL, Liang Y, Wang G, Lin X, Yang M, Karin M, Fu W, Feng GS. Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. Mol Cancer Res. 2022 Mar 1;20(3):337-349.

12. Li D, Xiong W, Wang Y, Feng J, He Y, Du J, Wang J, Yang M, Zeng H, Yang YG, Wu N, Chen S, Dong Z. SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors. Sci Immunol. 2022 Jan 21;7(67):eabj5501.

13. Feng P, Yang Q, Luo L, Sun Y, Lv W, Wan S, Guan Z, Xiao Z, Liu F, Li Z, Dong Z, Yang M. The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis. Theranostics. 2021 Sep 13;11(19): 9503-9518.(共同通讯作者)

14. Ji Y, Luo Z, Gao H, Dos Reis FCG, Bandyopadhyay G, Jin Z, Manda KA, Isaac R, Yang M, Fu W, Ying W, Olefsky JM. Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nat Metab. 2021 Sep;3(9):1163-1174.

15. He J, Zhao J, Quan Y, Hou X, Yang M, Dong Z. Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival. Front Immunol. 2021 Feb 9;11:617404. (共同通讯作者)

16. Li D, Wang Y, Yang M*, Dong Z*.mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet. Cell Death Differ. 2021 Jan 18. (共同通讯作者)

17. Zeng W, Ma H, Fan W, Yang Y, Zhang C, Arnaud Kombe Kombe J, Fan X, Zhang Y, Dong Z, Shen Z, Zhou Y, Yang M*, Jin T*. Structure determination of CAMP factor of Mobiluncus curtisii and insights into structural dynamics. Int J Biol Macromol. 2020 May 1;150:1027-1036. (共同通讯作者)

18. Zeng X, Liu G, Peng W, He J, Cai C, Xiong W, Chen S, Yang M*, Dong Z*. Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages. Cell Mol Immunol. 2020 Feb;17(2):153-162. (共同通讯作者)

19. Yang Q, Liu X, Liu Q, Guan Z, Luo J, Cao G, Cai R, Li Z, Xu Y, Wu Z, Xu M, Zhang S, Zhang F, Yang H, Lin X, Yang M, Wu Y, Gao Y, Flavell R, Hao J, Yin Z. Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδT17 differentiation and function. Cell Death Differ. 2020 Jul;27(7):2248-2262. 

20. Sun B, Mason S, Wilson RC, Hazard SE, Wang Y, Fang R, Wang Q, Yeh ES, Yang M, Roberts TM, Zhao JJ, Wang Q. Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers. Oncogene. 2020 Jan;39(1):50-63.

21. He J, Wang Y, Liu T, Liu G, Chen S, Li Q, Quan Y, Yang H, Feng J, Wang S, Yang M*, Dong Z*. Stage-specific requirement of kinase PDK1 for NK cells development and activation. Cell Death Differ. 2019 Oct;26(10):1918-1928. (共同通讯作者)

22. Li Y, Zeng W, Li Y, Fan W, Ma H, Fan X, Jiang J, Brefo-Mensah E, Zhang Y, Yang M, Dong Z, Palmer M, Jin T. Structure determination of the CAMP factor of Streptococcus agalactiae with the aid of an MBP tag and insights into membrane-surface attachment. Acta Crystallogr D Struct Biol. 2019 Aug 1;75(Pt 8):772-781.

23.  Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 Feb 5;29(2):457-474.

24. Sun B, Jensen NR, Chung D, Yang M, LaRue AC, Cheung HW, Wang Q. Synergistic effects of SHP2 and PI3K pathway inhibitors in GAB2-overexpressing ovarian cancer. Am J Cancer Res. 2019 Jan 1;9(1):145-159.

25. Wang J, Liu S, Hou B, Yang M, Dong Z, Qi H, Liu W. PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses. Front Immunol. 2018 Feb 28;9:371.

26. Chen S, Cai C, Li Z, Liu G, Wang Y, Blonska M, Li D, Du J, Lin X, Yang M, Dong Z. Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity. J Exp Med. 2017 Feb;214(2):475-489.

27. Yang M#, Chen S#, Du J, He J, Wang Y, Li Z, Liu G, Peng W, Zeng X, Li D, Xu P, Guo W, Chang Z, Wang S, Tian Z, Dong Z. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nat Commun. 2016 Sep 7;7:12730.(共同第一作者)

28. Chen S#, Yang M#, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z, Dong Z. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. Immunity. 2016 Aug 16;45(2):292-304.(共同第一作者)

29. Du J, Yang M, Chen S, Li D, Chang Z, Dong Z. PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model. Oncogene. 2016 Jun 23;35(25):3314-23.

30. Sun J, Yang M, Ban Y, Gao W, Song B, Wang Y, Zhang Y, Shao Q, Kong B, Qu X. Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway. PLoS One. 2016 Jan 20;11(1):e0147186.

31. Yang M, Liu Y, Ren G, Shao Q, Gao W, Sun J, Wang H, Ji C, Li X, Zhang Y, Qu X. Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization. Sci Rep. 2015 Sep 1;5:13674.

32. Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. J Exp Med. 2015 Feb 9;212(2):253-65.

33. Sun J, Feng A, Chen S, Zhang Y, Xie Q, Yang M, Shao Q, Liu J, Yang Q, Kong B, Qu X. Osteopontin splice variants expressed by breast tumors regulate monocyte activation via MCP-1 and TGF-β1. Cell Mol Immunol. 2013 Mar;10(2):176-82.

34. Zhang J, Ma D, Ye J, Zang S, Lu F, Yang M, Qu X, Sun X, Ji C. Prognostic impact of δ-like ligand 4 and Notch1 in acute myeloid leukemia. Oncol Rep. 2012 Oct;28(4):1503-11.

35. Shao Q, Ning H, Lv J, Liu Y, Zhao X, Ren G, Feng A, Xie Q, Sun J, Song B, Yang Y, Gao W, Ding K, Yang M, Hou M, Peng J, Qu X. Regulation of Th1/Th2 polarization by tissue inhibitor of metalloproteinase-3 via modulating dendritic cells. Blood. 2012 May 17;119(20):4636-44.

36. Li P, Liu K, Li L, Yang M, Gao W, Feng J, Lv Y, Qu X, Kong B. Reduced CMTM5 expression correlates with carcinogenesis in human epithelial ovarian cancer. Int J Gynecol Cancer. 2011 Oct;21(7):1248-55.

37. Zhang L, Li JM, Liu XG, Ma DX, Hu NW, Li YG, Li W, Hu Y, Yu S, Qu X, Yang MX, Feng AL, Wang GH. Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis. J Clin Immunol. 2011 Aug;31(4):606-14

38. Liu GX, Sun JT, Yang MX, Qi XM, Shao QQ, Xie Q, Qu X, Wei FC, Sun SZ. OPN promotes survival of activated T cells by up-regulating CD44 in patients with oral lichen planus. Clin Immunol. 2011 Mar;138(3):291-8.

39. Li L, Qu X, Sun J, Yang M, Song B, Shao Q, Zhang X, Jin W. Single-molecule-counting protein microarray assay with nanoliter samples and its application in the dynamic protein expression of living cells. Biosens Bioelectron. 2011 Apr 15;26(8):3688-91

40. Sun J, Feng A, Zhang Y, Sun S, Hu W, Yang M, Wei F, Qu X. Fucoidan increases TNF-alpha-induced MMP-9 secretion in monocytic cell line U937. Inflamm Res. 2010 Apr;59(4):271-6.

41. Yang M, Ma C, Liu S, Shao Q, Gao W, Song B, Sun J, Xie Q, Zhang Y, Feng A, Liu Y, Hu W, Qu X. HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia. Immunol Cell Biol. 2010 Feb;88(2):165-71.

42. Sun J, Zhang Y, Yang M, Zhang Y, Xie Q, Li Z, Dong Z, Yang Y, Deng B, Feng A, Hu W, Mao H, Qu X. Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A(2). Cell Mol Immunol. 2010 Jan;7(1):77-82.

43. Yang M, Ma C, Liu S, Sun J, Shao Q, Gao W, Zhang Y, Li Z, Xie Q, Dong Z, Qu X. Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin. Immunology. 2009 Sep;128(1 Suppl):e237-49

44. Yang M, Ma C, Sun J, Shao Q, Gao W, Zhang Y, Li Z, Xie Q, Dong Z, Qu X. Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells. Int Immunopharmacol. 2008 Dec 20;8(13-14):1754-60.

45. Zhao P, Li XG, Yang M, Shao Q, Wang D, Liu S, Song H, Song B, Zhang Y, Qu X. Hypoxia suppresses the production of MMP-9 by human monocyte-derived dendritic cells and requires activation of adenosine receptor A2b via cAMP/PKA signaling pathway. Mol Immunol. 2008 Apr;45(8):2187-95.

46. Qu X, Yang M, Zhang W, Liang L, Yang Y, Zhang Y, Deng B, Gao W, Liu J, Yang Q, Kong B, Gong F. Osteopontin expression in human decidua is associated with decidual natural killer cells recruitment and regulated by progesterone. In Vivo. 2008 Jan-Feb;22(1):55-61.

47. Yang MX, Qu X, Kong BH, Lam QL, Shao QQ, Deng BP, Ko KH, Lu L. Membrane type 1-matrix metalloproteinase is involved in the migration of human monocyte-derived dendritic cells. Immunol Cell Biol. 2006 Dec;84(6):557-62.

45. Qu X, Yang MX, Kong BH, Qi L, Lam QL, Yan S, Li P, Zhang M, Lu L. Hypoxia inhibits the migratory capacity of human monocyte-derived dendritic cells. Immunol Cell Biol. 2005 Dec;83(6):668-73.

获奖及荣誉：“暨南双百英才计划”杰出人才

学术兼职：  

广东省免疫学会第一届届理事会理事

广东省免疫学会女科学家工作委员会委员