杨恒文 研究员

职称：研究员

学科专业：免疫学

研究方向：

1.肠道微生物与免疫系统的相互调控；

2.代谢性疾病的免疫机制；

3.基于转基因动物疾病模型的小分子药物筛选。

电子邮箱：hengwenyang@jnu.edu.cn

导师类型：博导

个人介绍：杨恒文博士，2001年毕业于清华大学生物科学与技术系，获生物学学士学位；2007年获清华大学生物科学与技术系生物化学与分子生物学博士学位。随后赴美国克罗拉多大学博尔德分校从事博士后研究，回国后加入暨南大学生物医学转化研究院尹芝南院长团队，任研究员，博士生导师。主要研究肠道微生物与免疫在精神、代谢等重要疾病中的作用及其分子机制，研究成果发表在Nature、Nature communications、Cell Discovery等杂志；主持国自然面上项目等多个项目，参与教育部提名国家科学技术奖自然科学一等奖一项，广东省自然科学进步一等奖一项；担任广东省免疫学会理事，中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员，中国生物物理学会肠道菌群分会委员。

学习经历： 

1997.9-2001.6学士，清华大学生物科学与技术系（现生命科学院）。

2001.9-2007.1生物化学与分子生物学博士，清华大学生物科学与技术系（现生命科学院）。

工作经历：

2007.01 - 2013.06  博士后；美国科罗拉多大学博尔德校区。

2016.10 - 至今 副研究员/研究员，博导。暨南大学生物医学转化研究院。

主要论文：

1.   IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation. Mingyue Zhang#, Dehai Li, Jing Zhu, Xue Xia, Hua Zhang, Jie Wu, Shengli Wang, Anyi Deng, Qiong Wen, Jingyi Tan, Jianlei Hao, Jun Jiang, Xiucong Bao, Guodong Sun, Jiajing Lu, Quanli Yang, Hengwen Yang*, Guangchao Cao*, Zhinan Yin* and Qian Wang*. Cell Death and Disease (2024) 15:491 ; https://doi.org/10.1038/s41419-024-06887-0

2.   Multidimensional analysis of TMEM132A in pan-cancer: unveiling its potential as a biomarker for treatment response prediction. Zhang M, Wang S, He M, Zhang Z, Wu J, Sun H, Zhang H, Yang H. J Cancer. 2024 Jun 11;15(13):4386-4405. doi: 10.7150/jca.96396. eCollection 2024.

3.   Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus. Zhongzhen Li#, Zhiwei Lei#, Wanying Yang, Chunxia Jing, Xiaolin Sun, Guang Yang, Xiaozhen Zhao, Mingjiao Zhang, Miaomiao Xu, Yuanjia Tang, Qingwen Wang, Jing Zhao, Zixing Zhou, Zihao Wen, Xiaojing Chen, Qinglin Peng, Guochun Wang, Pingjing Zhang, Erwei Sun 7 8, Nan Shen, Weiguo Xu*, Zhanguo Li*, Hengwen Yang*, Zhinan Yin*.  Parasit Vectors. 2024 Jan 30;17(1):44. doi: 10.1186/s13071-024-06141-8.

4.   IL-27 signaling promotes adipocyte thermogenesis and energy expenditure. Qian Wang#, Dehai Li#, Guangchao Cao#, Qiping Shi#, Jing Zhu, Mingyue Zhang, Hao Cheng , Qiong Wen , Hao Xu , Leqing Zhu , Hua Zhang , Rachel Perry , Olga Spadaro , Yunfan Yang , Shengqi He , Yong Chen , Baocheng Wang , Guangqiang Li , Zonghua Liu , Caixian Yang , Xiaoli Wu , Libing Zhou , Qinghua Zhou , Zhenyu Ju , Hongyun Lu , Yongjie Xin , Xiaoyong Yang , Cunchuan Wang , Yong Liu , Gerald Shulman , Vishwa Dixit , Ligong Lu*, Hengwen Yang*, Richard A. Flavell*, Zhinan Yin*. Nature, 2021, Nov 24. doi: 10.1038/s41586-021-04127-5.

5.   Roux-en-Y Gastric Bypass improved insulin resistance via alteration of the human gut microbiome and alleviation of endotoxemia. Qiping Shi#, Qian Wang#, Hui Zhong, Dehai Li, Shuxing Yu, Hengwen Yang*, Cunchuan Wang*, Zhinan Yin*, BioMed Research International. 2021

6.   Metabolic Control of γδ T Cell Function. Meng Z#, Cao G#, Yang Q#, Yang H*, Hao J*, Yin Z*. Infect Microb Dis 2021;00(00):00–00. doi: 10.1097/ IM9.0000000000000054

7.   Perforin Acts as An Immune Regulator to Prevent NAFLD Progression. Qian Wang#*, Dehai Li#, Jing Zhu#, Mingyue Zhang, Hua Zhang, Guangchao Cao, Leqing Zhu, Qiping Shi, Jianlei Hao, Qiong Wen, Zonghua Liu, Hengwen Yang* and Zhinan Yin*. Front. Immunol. May 2020, Volume 11, Article 846, doi: 10.3389/ fimmu.2020.00846

8.   Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2. Qin-Li Wan#, Xiaodie Fu#, Wenyu Dai, Jing Yang, Zhenhuan Luo, Xiao Meng, Xiao Liu, Ruowei Zhong, Hengwen Yang*, Qinghua Zhou*. AGING 2020, 12(3):2840-2853

9.   Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity. Jing Zhu^#, Ruitian Cai^#, Yuxiang Tan^#, Xiuqing Wu, Qiong Wen, Zonghua Liu, Shu-Hua Ouyang, Zhinan Yin*, Hengwen Yang*. Journal of Functional Foods，Volume 64, January 2020, 103621

10.Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals. Qin‐Li Wan^#, Xiao Meng^#, Xiaodie Fu^#, Bohui Chen, Jing Yang,Hengwen Yang*, Qinghua Zhou*, AGING, 2019 Jun 21;11(12):3993-4010

11.NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer. Li Z#, Tang X#, Luo Y, Chen B, Zhou C, Wu X, Tang Z, Qi X, Cao G, Hao J, Liu Z, Wang Q, Yin Z, Yang H*. J Cell Physiol. 2019 Feb 20. 234(9):16178–16190. doi: 10.1002/jcp.28278.

12.Gut microbiota have blood types as human. Qizheng Wu#, Hui Zhong#, Yafei Zhai, Yanjiong Jia, Zhinan Yin, Min Chen^*, Hengwen Yang*, Peng George Wang^*. Sci Bull 63 (2018) 1311–1313,

13.Transmembrane domain dependent inhibitory function of FcγRIIB. Wang J, Li Z, Xu L*, Yang H*, Liu W*. Protein Cell. 2018 Dec;9(12):1004-1012. doi: 10.1007/s13238-018-0509-8.

14.Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice. Guangchao Cao#, Qian Wang#, Wanjun Huang#, Jiyu Tong, Dewei Ye, Yan He, Zonghua Liu, Xin Tang, Hao Cheng, Qiong Wen, Dehai Li, Hau-Tak Chau, Yiming Wen, Hui Zhong, Ziyu Meng, Hui Liu, Zhenzhou Wu, Liqing Zhao, Richard A Flavell, Hongwei Zhou, Aimin Xu, Hengwen Yang*, Zhinan Yin*. Cell Discovery (2017) 3, 17020; doi:10.1038/celldisc.2017.20

15.Remodeling of the gut microbiota and structural shifts in Preeclampsia patients in South China. Liu J#, Yang H#, Yin Z, Jiang X, Zhong H, Qiu D, Zhu F, Li R. Eur J Clin Microbiol Infect Dis. 2017 Apr;36(4):713-719, doi: 10.1007/s10096-016-2853-z.

16.A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Yang Hengwen#, Chen YZ#, Zhang Y#, Wang X, Zhao X, Godfroy JI 3rd, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. Nature Communications, 6(1), 1-‌12. 2015 Jan 7.

17.Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure. Chao L#, Lu L#, Yang Hengwen#, Zhu Y, Li Y, Wang Q, Yu X, Jiang S, Chen YH*.PLoS One. 2013 May 31;8(5): e66156.

18.Evidence for existence of a close association between CD14 and CXCR4 on monocytic cell line U937. Hengwen Yang, Canhui Lan, Ying-Hua Chen. Porgress in Natural Science. 2007

19.Antibody to CD14 like CXCR4-specific antibody 12G5 could inhibit CXCR4-dependent chemotaxis and HIV Env-mediated cell fusion. Hengwen Yang, Canhui Lan, Yi Xiao, Ying-Hua Chen. Immunol Lett. 2003, 88 (1): 27-30.

20.Characterization of interaction between C-domain on HIV-1 gp41 and the putative receptor protein p62. Hengwen Yang, Yi Xiao, Yun Lu, Ying-Hua Chen. Immunobiology. 2001, 203: 778-785.

获奖及荣誉：

1、中国医学科学院-中国2021年度重要医学进展（基础医学与生物学领域），发现IL-27信号调控肥胖和2型糖尿病的新机制    2022/04/17(排名2/7)

2、肿瘤精准介入治疗体系与智能诊断系统的建立与推广，2020年度广东省科技进步一等奖，省部级，广东省科技厅（排名12/15 ）2021

3、2021年暨南大学医学部学科建设贡献奖“杏林优秀学者”

学术兼职：

广东省免疫学会监事

中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员

中国生物物理学会肠道菌群分会委员