曹广超 副研究员

职称：副研究员

学科专业：基础医学

研究方向：免疫学

电子邮箱：gccao2016@jnu.edu.cn

个人介绍：广东省自然科学基金-杰出青年项目获得者。长期从事T细胞免疫的基础研究，发现了T细胞（尤其是γδ T细胞）亚群分化与效应功能的多种代谢、表观修饰调控机制；发现了介导溶酶体酸化的新的H+通道蛋白；并发现了免疫因子IL-27的新的生理功能，研究成果被中国医学科学院评选为“中国2021年度重要医学进展”。以（共同）通讯/第一作者在Nature、Cell Research、J Exp Med、J Clin Invest等杂志发表学术论文14篇，他引1760余次，H-Index 17。

导师类型：硕导

学习经历：

2011/09-2016/06   南开大学，生命科学学院，生化与分子生物学系，博士，导师：尹芝南

2007/09-2011/06   南开大学，生命科学学院生物科学专业，本科

工作经历：

2019/10-至今  暨南大学，生物医学转化研究院，副研究员

2016/09-2019/8  暨南大学，生物医学转化研究院，博士后，合作导师：尹芝南

2016/11-2018/01 耶鲁大学，免疫学系，访问学者，合作导师：Richard A Flavell

主要论文：

已发表（共同）通讯/第一作者论文

1.  Mingyue Zhang#, Dehai Li#, Jing Zhu#, Hua Zhang, Jie Wu, Shengli Wang, Anyi Den, Qiong Wen, Jingyi Ta, Xiucong Bao, Jiaqing Lu, Quanli Yan, Hengwen Yang*, Guangchao Cao*, Zhinan Yi* and Qian Wang*. IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cells mediated skin inflammation. Cell Death & Diseases. 2024.（Accepted, *co-corresponding author）

2.  Leqing Zhu#, Xichun Xia#, Guangqiang Li#, Chuyun Zhu#, Qingqing Li, Baocheng Wang, Nan-Xi Shi, Zhiwei Lei, Shuxian Yang, Zhanpeng Zhang, Haishan Li, Jingyi Tan, Zonghua Liu, Qiong Wen, Hui Zhong, Xue-Jia Lin, Guodong Sun, Xiucong Bao, Qian Wang*, Liehua Deng*, Lianghua Bin*, Guangchao Cao*, Zhinan Yin*. SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification. Cell Reports. 2023 Aug 1;42(8):112910. (*co-corresponding author)

3.  Zhiqiang Xiao#, Shanshan Wang#, Yixia Tian#, Wenkai Lv, Hao Sheng, Mingjie Zhan, Qiongxiao Huang, Zhanpeng Zhang, Leqing Zhu, Chuyun Zhu, Hui Zhong, Qiong Wen, Zonghua Liu, Jingyi Tan, Yan Xu, Meixiang Yang, Yumei Liu*, Richard A Flavell*, Quanli Yang*, Guangchao Cao*, Zhinan Yin*. METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells. Cell Reports. 2023 Jun 23;42(7):112684. (*co-corresponding author)

 4.   Zhenhua Li#, Quanli Yang#, Xin Tang#, Yiming Chen, Shanshan Wang, Xiaojie Qi, Yawen Zhang, Zonghua Liu, Jing Luo, Hui Liu, Yongbing Ba, Lianxia Guo, Baojian Wu, Fang Huang, Guangchao Cao*, Zhinan Yin*. Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse γδ T cells. Science Bulletin. 2022 Feb 67(4):408-426. (*co-corresponding author)

5.  Peng Li#, Xinhai Zhu#, Guangchao Cao#, Ruan Wu, Ke Li, Wenhui Yuan, Biyun Chen, Guodong Sun, Xichun Xia, Hua Zhang, Xiao Wang, Zhinan Yin*, Ligong Lu* and Yunfei Gao*. 1α,25(OH)2D3 reverses exhaustion and enhances anti-tumor immunity of human cytotoxic T cells. Journal for ImmunoTherapy of Cancer. 2022 Mar;10(3):e003477. (#co-first author)

 6.   Qian Wang#, Dehai Li#, Guangchao Cao#, Qiping Shi#, Jing Zhu, Mingyue Zhang, Hao Cheng, Qiong Wen, Hao Xu, Leqing Zhu, Hua Zhang, Rachel J. Perry, Olga Spadaro, Yunfan Yang, Shengqi He, Yong Chen, Baocheng Wang, Guangqiang Li, Zonghua Liu, Caixian Yang, Xiaoli Wu, Libing Zhou, Qinghua Zhou, Zhenyu Ju, Hongyun Lu, Yongjie Xin, Xiaoyong Yang, Cunchuan Wang, Yong Liu, Gerald I. Shulman, Vishwa D. Dixit, Ligong Lu*, Hengwen Yang*, Richard A. Flavell*, Zhinan Yin*. IL-27 signaling promotes adipocyte thermogenesis and energy expenditure. Nature. 2021 Dec;600(7888):314-318. (#co-first author)

7.   Leqing Zhu#, Zhiwei Lei#, Xichun Xia#, Yingying Zhang, Yuyuan Chen, Baocheng Wang, Jiawei Li, Guangqiang Li, Guang Yang, Guangchao Cao* and Zhinan Yin*. Yeast Shells Encapsulating Adjuvant AS04 as an Antigen Delivery System for a Novel Vaccine against Toxoplasma Gondii.ACS Appl. Mater. Interfaces. 2021, 13, 34, 40415-40428. (*co-corresponding author)

 8.  Jie Lu, Yanpeng Jiao, Guangchao Cao*, Zonghua Liu*. Multimode CaCO3/pneumolysin antigen delivery systems for inducing efficient cellular immunity for anti-tumor immunotherapy. Chemical Engineering Journal. 2021 Sep 15; 420(1): 129746. (*co-corresponding author)

 9.   Xichun Xia#, Guangchao Cao#, Guodong Sun#, Leqing Zhu, Yixia Tian, Yueqi Song, Chengbin Guo, Xiao Wang, Jingxiang Zhong, Wei Zhou, Peng Li, Hua Zhang, Jianlei Hao, Zhizhong Li, Liehua Deng*, Zhinan Yin*, Yunfei Gao*. GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis. Journal of Clinical Investigation. 2020 Oct 1;130(10):5180-5196. (#co-first author)

10.  Jiyu Tong#, Guangchao Cao#, Ting Zhang#, Esen Sefik, Maria Carolina Amezcua Vesely, James P Broughton, Shu Zhu, Huabin Li, Bin Li, Lei Chen, Howard Y Chang, Bing Su, Richard A Flavell*, Hua-Bing Li*. m6A mRNA methylation sustains Treg suppressive Functions. Cell Research. 2018; 28: 253-256. (#co-first author, citations > 200)

 11.  Guodong Sun#, Shuxian Yang#, Guangchao Cao#, Qianghua Wang, Jianlei Hao, Qiong Wen, Zhizhong Li, Kwok-Fai So, Zonghua Liu, Sufang Zhou, Yongxiang Zhao, Hengwen Yang, Libing Zhou*, Zhinan Yin*. gd T cells provide the early source of IFN-γ to aggravate lesions in spinal cord Injury. Journal of Experimental Medicine. 2018 Feb 5;215(2):521-535. (#co-first author)

12.  Guangchao Cao#, Qian Wang#, Wanjun Huang#, Jiyu Tong, Dewei Ye, Yan He, Zonghua Liu, Xin Tang, Hao Cheng, Qiong Wen, Dehai Li, Hau-Tak Chau, Yiming Wen, Hui Zhong, Ziyu Meng, Hui Liu, Zhenzhou Wu, Liqing Zhao, Richard A Flavell, Hongwei Zhou, Aimin Xu, Hengwen Yang* and Zhinan Yin*. Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice. Cell Discovery. 2017; 3: 17020. (#co-first author).

 13.  Guangchao Cao#, Qian Wang#, Guangqiang Li, Ziyu Meng, Hui Liu, Jiyu Tong, Wanjun Huang, Zonghua Liu, Yanqiong Jia, Jun Wei, Hongbo Chi, Hengwen Yang, Liqing Zhao, Zhenzhou Wu, Jianlei Hao* and Zhinan Yin*. mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-a. Journal of Leukocyte Biology. 2016. 100 (5) 1181-1189. (#co-first author).

 14.  Guangchao Cao#, Hua-Bing Li#, Zhinan Yin*, Richard A. Flavell*. Recent advances in dynamic m6A RNA modification. Open Biology. 2016; 6: 160003. (Review, citations > 200).

 15.  Guangchao Cao, Zhiqiang Xiao and Zhinan Yin*. Normalization cancer immunotherapy: blocking Siglec-15! Signal Transduct Target Ther. 2019; 4:10. (Research Highlight)

已发表共同作者论文

1. Hua-Bing Li#, Jiyu Tong#, Shu Zhu#, Pedro J. Batista, Erin E. Duffy, Jun Zhao, Will Bailis, Guangchao Cao, Lina Kroehling, Yuanyuan Chen, Geng Wang, James P. Broughton, Y. Grace Chen, Yuval Kluger, Matthew D. Simon, Howard Y. Chang, Zhinan Yin* & Richard A. Flavell*. m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature. 2017; 548, 338-342. (citations > 600)

 2. Ying Xie #, Yu Huang #, Zhi-Yong Li #, Weihua Jiang, Nan-Xi Shi, Yuanzhi Lu, Guangchao Cao, Zhinan Yin*, Xue-Jia Lin*. Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells. Mol Cancer. 2024 May 8;23(1):95.

3. Zhiqiang Xiao#, Shanshan Wang#, Liang Luo#, Wenkai Lv, Peiran Feng, Yadong Sun, Quanli Yang, Jun He, Guangchao Cao, Zhinan Yin* and Meixiang Yang*. Lkb1 orchestrates γδ T cell metabolic and functional fitness to control IL-17 mediated autoimmune hepatitis. Cell Mol Immunol. 2024 Jun;21(6):546-560.

4. Yuanyuan Duan#, Guangqiang Li#, Miaomiao Xu#, Xiaofei Qi, Mingxia Deng, Xuejia Lin, Zhiwei Lei, Yi Hu, Zhenghu Jia, Quanli Yang, Guangchao Cao, Zonghua Liu, Qiong Wen, Zhenhua Li, Jie Tang, Wei Kevin Zhang, Pingbo Huang, Limin Zheng, Richard A Flavell, Jianlei Hao*, Zhinan Yin*. CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity. Cell Mol Immunol. 2021 Aug;18(8):1934-1944.

 5. Quanli Yang#, Xia Liu#, Qihui Liu#, Zerong Guan, Jing Luo, Guangchao Cao, Ruitian Cai, Zhenhua Li, Yan Xu, Zengfeng Wu, Miaomiao Xu, Song Zhang, Fan Zhang, Hengwen Yang, Xuejia Lin, Meixiang Yang, Yangzhe Wu, Yunfei Gao, Richard Flavell, Jianlei Hao*, Zhinan Yin*. Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function. Cell Death Differ. 2020 Jul;27(7):2248-2262.

 6. Hongrong Ding#, Shujie Chen#, Xiaohan Pan#, Xiaoshuang Dai#, Guihua Pan, Ze Li, Xudong Mai , Ye Tian, Susu Zhang, Bingdong Liu, Guangchao Cao, Zhicheng Yao, Xiangping Yao, Liang Gao  , Li Yang, Xiaoyan Chen, Jia Sun, Hong Chen, Mulan Han, Yulong Yin, Guohuan Xu, Huijun Li, Weidong Wu, Zheng Chen, Jingchao Lin, Liping Xiang, Jun Hu*, Yan Lu*, Xiao Zhu*, Liwei Xie*.  Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis. J Cachexia Sarcopenia Muscle. 2021 Jun;12(3):746-768.

 7. Ziyu Meng, Guangchao Cao, Quanli Yang, Hengwen Yang*, Jianlei Hao*, Zhinan Yin*. Metabolic Control of γδ T Cell Function. Infectious Microbes & Diseases. 2021 Jan 20; 3:3.

 8. Qian Wang#*, Dehai Li# Jing Zhu#, Mingyue Zhang, Hua Zhang, Guangchao Cao, Leqing Zhu, Qiping Shi, Jianlei Hao, Qiong Wen, Zonghua Liu, Hengwen Yang*, Zhinan Yin*. Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD. Front Immunol. 2020 May 22;11:846.

 9. Hua Zhang#, Guodong Sun#, Xiaowei Li, Zhen Fu, Chengbin Guo, Guangchao Cao, Baocheng Wang, Qian Wang, Shuxian Yang, Dehai Li, Xichun Xia, Peng Li, Jing Zhu, Wei Zhou, Liangyan Zheng, Jingxia Li, Lei Zhang, Jianlei Hao, Libing Zhou, Frederic Bornancin, Zhizhong Li*, Zhinan Yin*, Yunfei Gao*. Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury. Science Bulletin. 2019; Apr. 22. DOI:10.1016/j.scib.2019.04.026.

 10. Zhenhua Li#, Xin Tang#, Yu Luo, Bangyu Chen, Congcong Zhou, Xiuqing Wu, Zhenping Tang, Xiaojie Qi, Guangchao Cao, Jianlei Hao, Zonghua Liu, Qingmin Wang, Zhinan Yin, Hengwen Yang*. NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer. J Cell Physiol. 2019 Feb 20. doi: 10.1002/jcp.28278.

 11. Hongru Zhang, Zheng Li, Li Wang, Gaofei Tian, Jun Tian, Zishan Yang, Guangchao Cao, Hong Zhou, Liqing Zhao, Zhenzhou Wu* and Zhinan Yin*. Critical role of myeloid-derived suppressor cells in tumor-induced liver immune suppression through inhibition of NKT cell function. Frontiers in Immunology. 2017 Feb 13;8:129.

12. Ziyu Meng, Jingya Wang, Yifang Yuan, Guangchao Cao, Shuobing Fan, Chao Gao, Li Wang, Zheng Li, Xiaoli Wu, Zhenzhou Wu, Liqing Zhao*, Zhinan Yin*. γδ T cells are indispensable for interleukin-23-mediated protection against Concanavalin A-induced hepatitis in hepatitis B virus transgenic mice. Immunology. 2017;151(1):43-55.

 13. Song Zhang, Ruifang Liang, Wei Luo, Chang Liu, Xiaoli Wu, Yanan Gao, Jianlei Hao, Guangchao Cao, Xi Chen, Jun Wei, Siyuan Xia, Zheng Li, Ti Wen, Yunyun Wu, Xinglong Zhou, Puyue Wang, Liqing Zhao, Zhengzhou Wu, Sidong Xiong, Xiaoming Gao, Xiang Gao, Yongyan Chen, Qing Ge, Zhigang Tian, and Zhinan Yin*. High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-γ dysregulation of CD4+ T cells. Hepatology. 2013; 57:1620-1631.

 14. Ti Wen, Yangguang Li, Meng Wu, Xiaolin Sun, Xiucong Bao, Yuquan Lin, Jianlei Hao, Lin Han, Guangchao Cao, Ziwen Wang, Yuxiu Liu, Zhenzhou Wu, Zhangyong Hong, Puyue Wang, Liqing Zhao, Zhanguo Li, Qingmin Wang* and Zhinan Yin*. Therapeutic effects of a novel tylophorine analog, NK-007, on collagen-induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation. Arthritis & Rheumatism. 2012; 64(9):2896-2906.

 15. Na Zhao#, Jianlei Hao#, Yuanyuan Ni#, Wei Luo, Ruifang Liang, Guangchao Cao, Yapu Zhao, Puyue Wang, Liqing Zhao, Zhigang Tian, Richard Flavell, Zhangyong Hong, Jihong Han, Zhi Yao, Zhenzhou Wu* and Zhinan Yin*. Vγ4 γδ T cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis. J Immunol. 2011 Nov 15;187(10):5007-14.

获奖及荣誉：

1、2022年，研究成果“发现IL-27信号调控肥胖和2型糖尿病的新机制”被中国医学科学院评选为“中国2021年度重要医学进展”；第6完成人。

2、2023年，广东省自然科学基金-杰出青年项目获得者。

学术兼职：

2020/12-2024/12  广东省免疫学会青年工作委员会委员；

Science Bulletin、Cell Reports Medicine等杂志审稿人。