个人简介:
周庆华,教授,博士生导师。分别于南开大学(2003)、清华大学(2006)和美国科罗拉多大学(2012)获得学士、硕士和博士学位。2015年从耶鲁大学博士后出站后到暨南大学工作至今。周庆华利用线虫、细胞和小鼠模型进行肿瘤机制、药物开发、跨代遗传、自噬衰老等方面的研究。近年来,在Science,Science Advances,Cell Research,Nature Communications,Advanced Science,Nucleic Acids Research等杂志上发表多篇论文,并获批多项国家发明专利。回国后获得“国家海外高层次人才”“彭磷基青年讲席教授”“王宽诚青年学者”等人才荣誉。
联系方式:手机l86-6466-l499,微信号Aprildad,电子邮件gene@email.jnu.edu.cn
研究方向:
1. 细胞自噬在肿瘤发生发展中的机制研究;
2. 抗肿瘤药物和抗衰老药物的筛选与开发;
3. 线虫为模型的跨度遗传和自噬衰老研究。
获批专利:
胆固醇生成基因标签在年轻乳腺癌患者预后预测中的应用(专利号:ZL 2020 1389455.9)
银杏酸C15:1在制备抗衰老药物中的用途(专利号:ZL 2020 1 0670036.6)
生物基因多位点性状的遗传解释完整度检测方法及系统(专利号:ZL 2016 1 0623216.2)
代表性论文:
Wan QL, Meng X, Wang C, Dai W, Luo Z, Yin Z, Ju Z, Fu X, Yang J, Ye Q, Zhang ZH, Zhou Q.(2022) Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans. Nature Communications. 13(1):768. doi: 10.1038/s41467-022-28469-4. [通讯作者,影响因子14.9]
Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q.(2022) CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response. Cell Death & Disease. 13(2):156. doi: 10.1038/s41419-022-04602-5. [通讯作者,影响因子8.5]
Wang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L, Yang H, Flavell RA, Yin Z.(2021) IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature. 600(7888):314-318. doi: 10.1038/s41586-021-04127-5. [参与作者,影响因子49.9]
Li J, Wang W, Zhou Q.(2021) Conserved role of ENDOG in promoting autophagy. Autophagy.17(4):1061-1062. doi: 10.1080/15548627.2021.1907513. [通讯作者,影响因子16.0]
Zhang X, Lv S, Luo Z, Hu Y, Peng X, Lv J, Zhao S, Feng J, Huang G, Wan QL, Liu J, Huang H, Luan B, Wang D, Zhao X, Lin Y, Zhou Q, Zhang ZN, Rong Z.(2021)MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo.Nucleic Acids Res. 19;49(7):4171-4185. doi: 10.1093/nar/gkab174. [共同通讯作者,影响因子16.9]
Wan QL, Meng X, Dai W, Luo Z, Wang C, Fu X, Yang J, Ye Q, Zhou Q.(2021)N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress.Science Advances. 2021 7(1):eabc3026. doi: 10.1126/sciadv.abc3026. [通讯作者,影响因子14.1]
Wang W, Li J, Tan J, Wang M, Yang J, Zhang ZM, Li C, Basnakian AG, Tang HW, Perrimon N, Zhou Q.(2021)Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.Nature Communications. 2021 Jan 20;12(1):476. doi: 10.1038/s41467-020-20780-2. [通讯作者,影响因子14.9]
He L, Sun Z, Li J, Zhu R, Niu B, Tam KL, Xiao Q, Li J, Wang W, Tsui CY, Hong Lee VW, So KF, Xu Y, Ramakrishna S, Zhou Q, Chiu K.(2021) Biomaterials.Electrical stimulation at nanoscale topography boosts neural stem cell neurogenesis through the enhancement of autophagy signaling. 268:120585. doi: 10.1016/j.biomaterials.2020.120585. [共同通讯作者,影响因子12.5]
Zhou Q, Li H, Li H, Nakagawa A, Lin JL, Lee ES, Harry BL, Skeen-Gaar RR, Suehiro Y, William D, Mitani S, Yuan HS, Kang BH, Xue D.(2016)Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization.Science. 2016 Jul 22;353(6297):394-9. doi: 10.1126/science.aaf4777. [第一作者,影响因子47.7].
Zhou Q, Li H, Xue D.(2011)Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Research. 21(12):1662-9. doi: 10.1038/cr.2011.182. [第一作者,影响因子25.6].