- 学习经历
- 工作经历
- 研究方向
- 参与项目
- 主要论文
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职称职务：武汉大学病毒学国家重点实验室主任，生命科学学院教授、博士生导师
学科专业：病毒学
研究方向：肿瘤病毒感染与致瘤机制
联系方式：
Email:klan@whu.edu.cn
教育经历/Education：
1989-1994 重庆医科大学临床医学专业，获医学学士学位
1995-1998 重庆医科大学病理生理学专业，获医学硕士学位
1998-2001 中南大学湘雅医学院病理生理学专业，获医学博士学位
工作经历与任职/Professional Experience：
1994-1995 四川省屏山县人民医院，住院医师
2002-2006 美国宾夕法尼亚大学医学院，博士后
2006-2016 中国科学院上海巴斯德研究所研究员，博士生导师，肿瘤病毒研究组组长，病原诊断技术研发中心主任
2011-2016 中国科学院上海巴斯德研究所副所长，纪委书记
2017-至今 武汉大学病毒学国家重点实验室主任，生命科学学院教授、博士生导师
学术兼职：
中国病理生理学会肿瘤专业委员会常委
中国微生物学会病毒专业委员会理事
Journal of Virology编委
Journal of Medical Virology副主编
获奖及荣誉：
国家万人计划领军人才（2016年）
上海市先进工作者（2015年）
上海领军人才（2015年）
国家创新人才推进计划中青年科技创新领军人才（2015年）
国家杰出青年科学基金获得者（2014年）
药明康德生命化学研究奖（2012年）
国务院政府特殊津贴获得者（2011年）
明治乳业生命科学奖（2010年）
中科院朱李月华优秀教师奖（2010年）
新世纪百千万人才工程国家级人选（2009年）
上海市浦江人才计划入选者（2008年）
中科院百人计划入选者（2006年）
美国白血病和淋巴瘤学会Special Fellow Award（2006年）
研究概述/Research Description：
主要从事肿瘤疱疹病毒感染及致瘤机理研究，在卡波氏肉瘤疱疹病毒(KSHV)潜伏感染与致瘤机理研究方面做出了系统性、原创性的研究工作：曾揭示KSHV关键开关分子RTA的表达调控机机理，提出RTA-LANA负反馈调控工作模型，得到领域内的广泛认可，对阐明KSHV潜伏感染的形成机制有重要的指导意义；曾利用KSHV作为工作模型，率先发现病毒包装自身及宿主miRNA，不仅揭示了病毒粒子一种新的构成成分，也鉴定了胞外游离型miRNA的一种新的存在形式，具有重要的学术价值；曾阐明KSHV通过操控Notch及BMP等重要信号转导通路参与致瘤的新机制，为发展相关肿瘤有效的治疗手段奠定了重要基础。
代表性论文/Publications:
1. Sun R, Tan X, Wang X, Wang X, Yang L, Robertson ES, Lan K*.Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues.PLoS Pathog. 2017 Jan 24;13(1):e1006167. doi: 10.1371/journal.ppat.1006167.
2. Li S, Hu H, He Z, Liang D, Sun R,Lan K*.Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway.PLoS Pathog. 2016 Oct 19;12(10):e1005900. doi: 10.1371/journal.ppat.1005900.
3. Yang Y, Zhang J, Xia T, Li G, Tian T, Wang M, Wang R, Zhao L, Yang Y, Lan K*, Zhou W*.MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like?1 in hepatocellular carcinoma.Oncol Rep. 2016 Nov;36(5):2553-2562. doi: 10.3892/or.2016.5129.
4. Dong W, Chen Q, Hu Y, He D, Liu J, Yan H, Lan K*, Zhang C*.Epidemiological and clinical characteristics of respiratory viral infections in children in Shanghai, China.Arch Virol. 2016 Jul;161(7):1907-13. doi: 10.1007/s00705-016-2866-z.
5. Hu H, Dong J, Liang D, Gao Z, Bai L, Sun R, Hu H, Zhang H, Dong Y, Lan K*. Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor.J Virol. 2015 Nov 4;90(3):1158-68. doi: 10.1128/JVI.01392-15.
6. Jia B, Guo M, Li G, Yu D, Zhang X, Lan K*, Deng Q*.Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7.J Virol. 2015 Feb 15;89(4):2041-51. doi: 10.1128/JVI.03106-14. Epub 2014 Nov 26.
7. Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H,Lan K*. Kaposi's Sarcoma-Associated Herpesvirus-Encoded Replication and Transcription Activator Impairs Innate Immunity via Ubiquitin-Mediated Degradation of Myeloid Differentiation Factor 88.J Virol. 2015 Jan 1;89(1):415-27. doi: 10.1128/JVI.02591-14. Epub 2014 Oct 15.
8. Liang D , Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao S, Lan K*. Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis. PLoS Pathog.2014 Jul 10;10(7):e1004253.
9. Qi Z, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y,Lan K*, Deng Q*. Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice. J Virol. 2014 Jul;88(14):8045-56. doi: 10.1128/JVI.01024-14.
10. Sun R, Liang D, Gao Y,Lan K*. Kaposi's Sarcoma-Associated Herpesvirus- Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency. J Virol. 2014 Jul 1;88(13):7331-7344.
11. Han J, Wang L, Liu J, Jin M, Hao F, Zhang P, Zhang Z, Wen D, Wu X, Liu G, Ji L, Xu D, Zhou D, Leng Q,Lan K*, Zhang C*. Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus. J Virol. 2014 Jun;88(11):6506-11.
12. Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H, Lan K*. Latency-Associated Nuclear Antigen of Kaposi Sarcoma-Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1. Cancer Res. 2014 Apr 1;74(7):2026-37.
13. Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML,Lan K*, Deng Q*. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection.J Virol. 2014 Mar;88(5):3004-15.
14. Xia T, Lévy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA,Lan K*, Wei Y*.The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factor β (TGF-β) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia. J Biol Chem. 2013 Jan 18;288(3):1785-94.
15. Yang Y, Xia T, Li N, Zhang J, Yang Y, Cong W, Deng Q,Lan K*, Zhou W*. Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma. Protein Cell. 2013 Jan;4(1):71-81.
16. Lin X, Li X, Liang D, Lan K*. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirus virions. J Virol. 2012 Dec;86(23):12717-30.
17. Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES,Lan K*. Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-Jκ and Are Responsible for LANA-Mediated RTA Repression. J Virol. 2012 May;86(9):4956-69
18. Liang D, Lin X,Lan K*. Looking at Kaposi's Sarcoma-Associated Herpesvirus-Host Interactions from a microRNA Viewpoint. Front Microbiol. 2012 Jan 11;2:271. (Invited review)
19. Liu Y, Sun R, Lin X, Liang D, Deng Q,Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5. J Virol. 2012 Feb;86(3):1372-81.
20. Li X, Liang D, Lin X, Robertson ES,Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. J Virol. 2011 Sep;85(17):8606-15.
21. Lin X, Liang D, He Z, Deng Q, Robertson ES,Lan K*. miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA. PLoS One. 2011 Jan 20;6(1):e16224.
22. Liang D, Gao Y, Lin X, He Z, Zhao Q, Deng Q,Lan K*. A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε. Cell Res. 2011 May;21(5):793-806.
23. Wang X, He B, Zhang Z, Liu T, Wang H, Li X, Zhang Q,Lan K, Lu X, Wen H*. Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors. Virol J. 2010 Mar 17;7:62.
24. He Z, Liu Y, Liang D, Wang Z, Robertson ES,Lan K*. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol. 2010 Feb;84(4):2047-62.
25.Lan K, Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES. Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor. Cancer Biol Ther. 2009 Nov;8(22):2136-43.
26. Liu Y, Cao Y, Liang D, Gao Y, Xia T, Robertson ES,Lan K*. Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element. Virology. 2008 Oct 25;380(2):264-75.
27.Lan K, Verma SC, Murakami M, Bajaj B, Kaul R, Robertson ES. Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein. Proc Natl Acad Sci USA. 2007 Oct 9;104(41):16287-92.
28.Lan K, Choudhuri T, Murakami M, Kuppers DA, Robertson ES.Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitro.J Virol. 2006 Jul;80(13):6411-9.
29. Lan K, Murakami M, Choudhuri T, Kuppers DA, Robertson ES. Intracellular-activated Notch1 can reactivate Kaposi's sarcoma-associated herpesvirus from latency.Virology. 2006 Aug 1;351(2):393-403.
30. Lan K, Kuppers DA, Verma SC, Sharma N, Murakami M, Robertson ES. Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency. J Virol. 2005 Jun;79(12):7453-65.
31. Lan K, Kuppers DA, Robertson ES. Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathway. J Virol. 2005 Mar;79(6):3468-78.
32.Lan K,Kuppers DA, Verma SC, Robertson ES.Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency.J Virol. 2004 Jun;78(12):6585-94.