蒋争凡

邮箱：jiangzf@pku.edu.cn

职称：教授/研究员

地址：北京市海淀区颐和园路5号，北京大学，金光生命科学大楼

个人介绍：

1987－1994年在兰州大学生物系学习，分获学士及硕士学位，1997年于北京大学获博士学位，1999年-2006年分别在美国克利夫兰医学中心及Scripps研究所从事博士后研究，现为北京大学“长江学者”特聘教授、北京大学长聘教授、北大-清华生命科学联合中心高级研究员，国家“973计划”项目首席科学家。

从事天然免疫及其细胞信号转导研究，在Cell、Immunity、Nature Immunology、JEM、PNAS等国际学术期刊上发表了多篇论文。曾获“国家杰出青年科学基金”和“谈家桢生命科学创新奖”，2014年获全国百篇优秀博士学位论文指导老师奖。

作为项目负责人主持了国家自然科学基金委的杰出青年基金、重点项目、重大研究计划及科技部“973”项目。

教育经历：

1994 - 1998, 理学博士, 细胞生物学, 北京大学

1991 - 1994, 理学硕士, 细胞生物学, 兰州大学

1987 - 1991, 理学学士, 细胞生物学, 兰州大学

工作经历：

2012-至今，高级研究员，北京大学-清华大学生命科学联合中心

2011-至今，教育部“长江学者”特聘教授

2011-2012，研究员，北京大学-清华大学生命科学联合中心

2006-2011, “百人计划”研究员, 北京大学生命科学学院

2003-2006, Research associate (博士后), The Scripps Research Institute, La Jolla, CA, USA

1999-2003, Research associate (博士后), The Lerner Research Institute, CCF, Cleveland, Ohio, USA

1997-1999, 博士后, 北京大学生命科学学院

社会服务工作：

1. 2010-2016, 国家自然科学基金委专家组成员, 国家自然科学基金委

2. 2010-至今, 国家自然科学基金委重大研究计划专家组成员, 国家自然科学基金委

荣誉奖励：

全国优秀博士学位论文指导教师，2014年

谈家桢生命科学创新奖，2013年

教育部“长江学者”特聘教授，2011年

国家杰出青年科学基金，2010年

教育部“新世纪优秀人才”，2007年

美国癌症基金会博士后奖学金，2005年

国际细胞因子学会优秀博士后论文一等奖，2002年

杂志编辑：

Editor, Scientific Reports, 2010-至今

Editor, J Bio Chem, 2016-2021

科研领域：

天然免疫及其相关的细胞信号转导研究

1）细胞识别病原微生物，激活天然免疫的分子机制；

2）泛素化参与抗病毒信号通路的机制；

3）天然免疫活化引发I型干扰素及其它重要细胞因子产生与调控的分子机制；

4）天然免疫活化后细胞因子分泌的机制；

5）天然免疫关键信号分子的调节和多种疾病（过敏反应、自身免疫病及慢性炎症）的相互关系；

6）重要信号分子的结构及功能。

代表性论文：

1. Tao J, Zhang X, Jin J, Du X, Lian T, Yang J, Zhou X, Jiang Z*, Su X*, 2017, Non-specific DNA binding by N-terminal domain promotes activation of human cyclic GMP-AMP synthase. J Immunology, In press.
 2. Wang Y, Ning X, Gao P, Wu S, Sha M, Lv M, Zhou X, Gao J, Fang R, Meng G, Su X, Jiang Z*. 2017, Inflammasome activation triggers caspases-mediated cleavage of cGAS to regulate responses to DNA virus infection. Immunity, 46: 1-12.
 3. Chen Y, Wang L, Jin J, Luan Y, Chen C, Li Y, Chu H, Wang X, Liao G, Yu Y, Teng H, Wang Y, Pan W, Fang L, Liao L, Jiang Z, Ge X, Li B, and Wang P. 2017, p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation. JEM, 214 (4):1-20.
 4. Tao J, Zhou X, Jiang Z*. 2016, cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling. IUBMB Life. 68(11): 858-870.
 5. Gao J, Tao J, Liang W, Jiang Z*. 2016, Cyclic (di)nucleotides: the common language shared by Microbe and Host. Current Opinion in Microbiology. 30: 79–87.
 6. Zhang H, Han M, Tao J, Ye Z, Du X, Deng M, Zhang X, Li L, Jiang Z*, Su X*. 2015, Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep. 16: 18035
 7. Gao J, Tao J, Liang W, Zhao M, Du X, Cui S, Duan H, Kan B, Su X, Jiang Z*. 2015, Identification and characterization of phosphodiesterase V-cGAPs that specifically degrade 3'3'-cyclic GMP-AMP. Cell Research. 25: 539-550.
 8. Wang Y, Lian Q, Yang B, Yan S, Zhou H, He L, Lin G, Lian Z, Jiang Z, Sun B*. 2015, TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLOS Pathogens DOI:10.1371/journal.ppat.1005012
 9. Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song Y, Liu H, Li C, Chen M, Wang W, Zhao Y, Jiang Z, Wang H, Wong C, Wang C, Zhou Z. 2015, The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor molecule TRAF6. Nature Immunology. 16 (3): 246-257.
 10. Zhou Z, Jia X, Xue Q, Dou Z, Ma Y, Zhao Z, Jiang Z, He B, Jin Q, Wang J*. 2014, TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. Proc Natl Acad Sci USA.111 (2): E245-E254.
 11. Chen H. and Jiang Z*. 2013, The essential adaptors of innate immune signaling. Protein & Cell. 4(1): 27–39.
 12. Huang YH, Liu XY, Du XX, Jiang Z, Su XD*. 2012, The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat Struct Mol Biol.19(7): 728-30.
 13. Zhou X, You F, Chen H, Jiang Z*. 2012, Poly(C)-binding protein 1 mediates house-keeping degradation of mitochondrial antiviral signaling (MAVS). Cell Research.22 (4): 717-727.
 14. Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z*. 2011, Activation of STAT6 by STING is Critical for Antiviral Innate Immunity. Cell.147 (2): 436-446.
 15. You FP, Sun H, Zhou X, Sun WX, Liang SM, Zhai ZH & Jiang Z*. 2009, PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nature Immunology. 10: 1300-1308.
 16. Sun W, Li Y, Chen L, Chen H, You F, Zhou X, Zhou Y, Zhai Z, Chen D, Jiang Z*. 2009, ERIS, an ER IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci USA. 106 (21): 8653-8.
 17. Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z*, Li X*. 2008, Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kB activation. J Biol Chem. 283 (21): 14654-64.
 18. Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson I A, Olson A, Beutler B. 2006, Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci USA. 103 (29): 10961-66.
 19. Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B. 2005, CD14 is required for MyD88-independent LPS signaling. Nat Immunology. 6(6): 565-70.
 20. Jiang Z, Mak TW, Sen G, Li X. 2004, Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci USA. 101(10): 3533-8.
 21. Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X. 2003 Poly (I-C)-induced TLR3-mediated activation of NFkappa B and MAP kinase is through an IRAK-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem. 278(19): 16713-9.
 22. Jiang Z, Johnson HJ, Nie H, Qin J, Bird TA, Li X. 2003, Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex. J Biol Chem. 278(13): 10952-6.
 23. Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X. 2002, Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol. 22(20): 7158-67.
 24. Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X and Hoebe K, 2006, Genetic Analysis of Host Resistance: Toll-like Receptor Signaling and Immunity at Large. Annual Review of Immunology 24: 353-89.
 25. Qian Y, Zhao Z, Jiang Z, Li X. 2002, Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells. Proc Natl Acad Sci USA. 99(14): 9386-91.
 26. Li X, Commane M, Jiang Z, Stark GR. 2001, IL-1-induced NFk B and JNK activation diverge at IRAK. Proc Natl Acad Sci USA. 98(8): 4461-5.
 27. Jiang Z, Hong X, Long H, Zhai ZH, 2000, Ceramides induce apoptosis in Hela cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. Cell Mol Life Sci. 57(7): 1117-25.
 28. Schabbauer G, Luyendyk J, Crozat K, Jiang Z, Mackman N, Bahram S, Georgel P. 2008, TLR4/CD14-mediated PI3K activation is an essential component of interferon -dependent VSV resistance in macrophages. Mol Immunol. 45(10):2790-6.
 29. M. Otsuka, Q. Jing, P. Georgel, New, J. Chen, J. Mols, Y.J. Kang, Z. Jiang, S. C. Das, A. K. Pattnaik, J. Carlos de la Torre, B. Beutler and J. Han. 2007, Hypersusceptibility to vesicular stomatitis virus infection in Dicer-deficient mice is due to impaired miR24 and miR93 expression. Immunity, 27: 123-134.
 30. Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X. 2007, Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkB activation pathways bifurcate at IRAK modification. J Biol Chem. 282(9):6075-89.
 31. Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z, Li X, Stark GR, Harrington J, Sherf B. 2004, Identification of a human NFkB-activating protein, TAB3. Proc Natl Acad Sci USA. 101(7): 2028-33.
 32. Georgel P, Jiang Z, Kunz S, Janssen E, Mols J, Hoebe K, Bahram S, Oldstone MB, Beutler B. 2007, Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362(2): 304-313.
 33. Huber M, Kalis C, Keck S, Jiang Z, Georgel P, et al. 2006 R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. Eur J Immunol. 36: 701-11.
 34. Hoebe K. Jiang Z, George P, Tabeta K, Janssen E, Du X, and Beutler B. 2006, TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy. Current Pharmaceutical Design 12: 4123-34.
 35. Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B. 2005, A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.Infect Immun. 73: 4512-21.
 36. Hoebe K, Jiang Z, Tabeta K, Du X, Georgel P, Crozat K, Beutler B. 2006, Genetic analysis of innate immunity. Adv Immunol. 91: 175-226.
 37. Beutler B, Georgel P, Rutschmann S, Jiang Z, Croker B, Crozat K. 2005, Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief Funct Genomic Proteomic. 4:203-13.
 38. Zhou Z, Hoebe K, Du X, Jiang Z, Shamel L, Beutler B. 2005, Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation. Eur J Immunol. 35 (6): 1918-27.
 39. Qin J, Jiang Z, Qian Y, Casanova JL, Li X. 2004, IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. J Biol Chem. 279(25): 26748-53.
 40. Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR. 2004, Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation. J Biol Chem. 279(36): 37670-6.
 41. Nguyen H, Chatterjee-Kishore M, Jiang Z, Qing Y, Ramana CV, Bayes J, Commane M, Li X, Stark GR. 2003, IRAK-dependent phosphorylation of Stat1 on serine 727 in response to IL-1 and effects on gene expression. J Interferon Cytokine Res. 23 (4): 183-92.