个人简介
杨恒文博士,2001年毕业于清华大学生物科学与技术系,获生物学学士学位;2007年获清华大学生物科学与技术系生物化学与分子生物学博士学位。随后赴美国克罗拉多大学博尔德分校从事博士后研究,回国后加入暨南大学生物医学转化研究院尹芝南院长团队,任副研究员,博士生导师。主要研究肠道微生物与免疫在精神、代谢等重要疾病中的作用及其分子机制,研究成果发表在Nature、Nature communications、Cell Discovery等杂志;主持国自然面上项目等多个项目,参与教育部提名国家科学技术奖自然科学一等奖一项,广东省自然科学进步一等奖一项;担任广东省免疫学会理事,中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员,中国生物物理学会肠道菌群分会委员。
联系方式
电子邮箱:hengwenyang@jnu.edu.cn
地址:暨南大学北门梁仲景楼8楼808
研究方向
1.肠道微生物与免疫系统的相互调控;
2.代谢性疾病的免疫机制;
3.基于转基因动物疾病模型的小分子药物筛选。
学术兼职
广东省免疫学会理事
中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员
中国生物物理学会肠道菌群分会委员
承担课题
1.磷脂酰丝氨酸受体参与凋亡细胞清除的分子机制研究, 广州市科信局科学研究专项, 项目编号201607010256。2016-2019,项目负责人。
2.γδ T细胞与肠道菌群之间的相互调控及其分子机制,国家自然科学基金重大国际合作项目,项目编号31420103901。2015-2019.参与。
3. 免疫功能调控的分子机制创新引智基地. 国家外专局、教育部“111”创新引智基地. 项目编号B16021。2016-2020.核心成员。
4. γδ T细胞和IL-27在脂肪肝中的作用及其分子机制广东省科技厅重大基础研究培育项目,项目编号2014A030308003。2015-2019.第二负责人。
5. 结核病生物数据库的建立及临床应用,广东省公益研究与能力建设专项,广东省科技厅,2016A020216021,2016-2018(合作单位负责人)
6. γδ T细胞介导肿瘤免疫的分子机制,国家自然科学基金委重点项目,项目编号3183000021。2019-2023,子课题负责人。
7. 锰缺乏通过肠道菌群失衡介导抑郁症及其分子机制,国家自然科学基金面上项目,项目编号32070121,2021-2024,项目负责人
主要论文
1. IL-27 signaling promotes adipocyte thermogenesis and energy expenditure. Qian Wang#, Dehai Li#, Guangchao Cao#, Qiping Shi#, Jing Zhu, Mingyue Zhang, Hao Cheng , Qiong Wen , Hao Xu , Leqing Zhu , Hua Zhang , Rachel Perry , Olga Spadaro , Yunfan Yang , Shengqi He , Yong Chen , Baocheng Wang , Guangqiang Li , Zonghua Liu , Caixian Yang , Xiaoli Wu , Libing Zhou , Qinghua Zhou , Zhenyu Ju , Hongyun Lu , Yongjie Xin , Xiaoyong Yang , Cunchuan Wang , Yong Liu , Gerald Shulman , Vishwa Dixit , Ligong Lu*, Hengwen Yang*, Richard A. Flavell*, Zhinan Yin*. Nature, 2021, Nov 24. doi: 10.1038/s41586-021-04127-5.
2. Roux-en-Y Gastric Bypass improved insulin resistance via alteration of the human gut microbiome and alleviation of endotoxemia. Qiping Shi#, Qian Wang#, Hui Zhong, Dehai Li, Shuxing Yu, Hengwen Yang*, Cunchuan Wang*, Zhinan Yin*, BioMed Research International. 2021
3. Metabolic Control of γδ T Cell Function. Meng Z#, Cao G#, Yang Q#, Yang H*, Hao J*, Yin Z*. Infect Microb Dis 2021;00(00):00–00. doi: 10.1097/ IM9.0000000000000054
4. Perforin Acts as An Immune Regulator to Prevent NAFLD Progression. Qian Wang#*, Dehai Li#, Jing Zhu#, Mingyue Zhang, Hua Zhang, Guangchao Cao, Leqing Zhu, Qiping Shi, Jianlei Hao, Qiong Wen, Zonghua Liu, Hengwen Yang* and Zhinan Yin*. Front. Immunol. May 2020, Volume 11, Article 846, doi: 10.3389/ fimmu.2020.00846
5. Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2. Qin-Li Wan#, Xiaodie Fu#, Wenyu Dai, Jing Yang, Zhenhuan Luo, Xiao Meng, Xiao Liu, Ruowei Zhong, Hengwen Yang*, Qinghua Zhou*. AGING 2020, 12(3):2840-2853
6. Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity. Jing Zhu#, Ruitian Cai#, Yuxiang Tan#, Xiuqing Wu, Qiong Wen, Zonghua Liu, Shu-Hua Ouyang, Zhinan Yin*, Hengwen Yang*. Journal of Functional Foods,Volume 64, January 2020, 103621
7. Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals. Qin‐Li Wan#, Xiao Meng#, Xiaodie Fu#, Bohui Chen, Jing Yang,Hengwen Yang*, Qinghua Zhou*, AGING, 2019 Jun 21;11(12):3993-4010
8. NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer. Li Z#, Tang X#, Luo Y, Chen B, Zhou C, Wu X, Tang Z, Qi X, Cao G, Hao J, Liu Z, Wang Q, Yin Z, Yang H*. J Cell Physiol. 2019 Feb 20. 234(9):16178–16190. doi: 10.1002/jcp.28278.
9. Gut microbiota have blood types as human. Qizheng Wu#, Hui Zhong#, Yafei Zhai, Yanjiong Jia, Zhinan Yin, Min Chen*, Hengwen Yang*, Peng George Wang*. Sci Bull 63 (2018) 1311–1313,
10. Transmembrane domain dependent inhibitory function of FcγRIIB. Wang J, Li Z, Xu L*, Yang H*, Liu W*. Protein Cell. 2018 Dec;9(12):1004-1012. doi: 10.1007/s13238-018-0509-8.
11. Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice. Guangchao Cao#, Qian Wang#, Wanjun Huang#, Jiyu Tong, Dewei Ye, Yan He, Zonghua Liu, Xin Tang, Hao Cheng, Qiong Wen, Dehai Li, Hau-Tak Chau, Yiming Wen, Hui Zhong, Ziyu Meng, Hui Liu, Zhenzhou Wu, Liqing Zhao, Richard A Flavell, Hongwei Zhou, Aimin Xu, Hengwen Yang*, Zhinan Yin*. Cell Discovery (2017) 3, 17020; doi:10.1038/celldisc.2017.20
12. Remodeling of the gut microbiota and structural shifts in Preeclampsia patients in South China. Liu J#, Yang H#, Yin Z, Jiang X, Zhong H, Qiu D, Zhu F, Li R. Eur J Clin Microbiol Infect Dis. 2017 Apr;36(4):713-719, doi: 10.1007/s10096-016-2853-z.
13. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Yang Hengwen#, Chen YZ#, Zhang Y#, Wang X, Zhao X, Godfroy JI 3rd, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. Nature Communications, 6(1), 1-12. 2015 Jan 7.
14. Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure. Chao L#, Lu L#, Yang Hengwen#, Zhu Y, Li Y, Wang Q, Yu X, Jiang S, Chen YH*.PLoS One. 2013 May 31;8(5): e66156.
15. Evidence for existence of a close association between CD14 and CXCR4 on monocytic cell line U937. Hengwen Yang, Canhui Lan, Ying-Hua Chen. Porgress in Natural Science. 2007
16. Antibody to CD14 like CXCR4-specific antibody 12G5 could inhibit CXCR4-dependent chemotaxis and HIV Env-mediated cell fusion. Hengwen Yang, Canhui Lan, Yi Xiao, Ying-Hua Chen. Immunol Lett. 2003, 88 (1): 27-30.
17. Characterization of interaction between C-domain on HIV-1 gp41 and the putative receptor protein p62. Hengwen Yang, Yi Xiao, Yun Lu, Ying-Hua Chen. Immunobiology. 2001, 203: 778-785.